BDBM504515 (R)-4-(3-Fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadiazol-3-yl)phenyl)-5-phenylmorpholin-3-one::US11066396, Example 2

SMILES Fc1cc(ccc1-c1noc(n1)C(F)(F)F)N1[C@@H](COCC1=O)c1ccccc1

InChI Key InChIKey=ZJEARMCIZNTTEM-HNNXBMFYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 504515   

TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504515((R)-4-(3-Fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadi...)
Affinity DataIC50:  5.30nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504515((R)-4-(3-Fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadi...)
Affinity DataIC50:  4.60E+3nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504515((R)-4-(3-Fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadi...)
Affinity DataIC50:  18nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504515((R)-4-(3-Fluoro-4-(5-(trifluoromethyl)-1,2,4-oxadi...)
Affinity DataIC50:  480nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent