BDBM50452258 CHEMBL4208907
SMILES Cc1cc(CC(=O)Nc2ccn(Cc3ccc(cn3)C#N)n2)ccc1OCC(F)(F)F
InChI Key InChIKey=ATAZIWXKOZRZRN-UHFFFAOYSA-N
Data 5 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 5 hits for monomerid = 50452258
Affinity DataIC50: 4.60E+4nMAssay Description:Inhibition of human CYP3A4 using testosterone as substrate preincubated for 30 minsMore data for this Ligand-Target Pair
TargetVoltage-dependent T-type calcium channel subunit alpha-1G(Homo sapiens (Human))
Idorsia Pharmaceuticals
Curated by ChEMBL
Idorsia Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 2.20nMAssay Description:Inhibition of recombinant Cav3.1 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
TargetVoltage-dependent T-type calcium channel subunit alpha-1I(Homo sapiens (Human))
Idorsia Pharmaceuticals
Curated by ChEMBL
Idorsia Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of recombinant Cav3.3 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
TargetVoltage-dependent T-type calcium channel subunit alpha-1H(Homo sapiens (Human))
Idorsia Pharmaceuticals
Curated by ChEMBL
Idorsia Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 7nMAssay Description:Inhibition of recombinant Cav3.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair
TargetVoltage-dependent L-type calcium channel subunit alpha-1C(Homo sapiens (Human))
Idorsia Pharmaceuticals
Curated by ChEMBL
Idorsia Pharmaceuticals
Curated by ChEMBL
Affinity DataIC50: 3.31E+3nMAssay Description:Inhibition of recombinant Cav1.2 (unknown origin) expressed in HEK293 cells assessed as decrease in calcium flux preincubated for 3 mins followed by ...More data for this Ligand-Target Pair