BDBM50452557 CHEMBL4206677::US11028051, Cmpd 55

SMILES CC(C)OC(=O)N[C@@H]1C[C@H](C)N(C(C)=O)c2ccc(cc12)-c1cc[nH]c1

InChI Key InChIKey=NGBVNAZGPQQGHB-SCLBCKFNSA-N

Data  2 IC50  6 Kd

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 8 hits for monomerid = 50452557   

TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataIC50:  2.48E+3nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 1 (49 to 170 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by s...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataIC50:  410nMAssay Description:Inhibition of recombinant human BRD2 bromodomain 2 (342 to 460 residues) using biotin labeled peptide substrate preincubated for 15 mins followed by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataKd:  77nMAssay Description:Binding affinity to His-tagged BRD2 bromodomain 2 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2 [348-455](Homo sapiens (Human))
St. Jude Children'S Research Hospital

US Patent
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataKd:  20nMAssay Description:Binding of compounds to BRD2 was monitored using an ITC200 (Microcal, Piscataway, N.J.). Either Brd2.1 (74-194) or Brd2.2 (348-455) was dialyzed over...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataKd:  20nMAssay Description:Binding affinity to BRD2 bromodomain 2 (348 to 455 residues) (unknown origin) by ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataKd:  104nMAssay Description:Binding affinity to His-tagged BRD2 bromodomain 1 (unknown origin) by SPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBromodomain-containing protein 2 [74-94](Homo sapiens (Human))
St. Jude Children'S Research Hospital

US Patent
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataKd:  92nMAssay Description:Binding of compounds to BRD2 was monitored using an ITC200 (Microcal, Piscataway, N.J.). Either Brd2.1 (74-194) or Brd2.2 (348-455) was dialyzed over...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetBromodomain-containing protein 2(Homo sapiens (Human))
St. Jude Children'S Research Hospital

Curated by ChEMBL
LigandPNGBDBM50452557(CHEMBL4206677 | US11028051, Cmpd 55)
Affinity DataKd:  92nMAssay Description:Binding affinity to BRD2 bromodomain 1 (74 to 194 residues) (unknown origin) by ITCMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed