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BDBM50455976 CHEMBL544476

SMILES: Cl.Clc1cc(Cl)cc(c1)C(=O)NC(=O)NC1CN2CCC1CC2

InChI Key: InChIKey=XMVORBFDCHHQRC-UHFFFAOYSA-N

Data: 1 Kd

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50455976   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50/IC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Serotonin 3a (5-HT3a)/3b (5-HT3b) receptor


(Rattus norvegicus-RAT)
BDBM50455976
PNG
(CHEMBL544476)
Show SMILES Clc1cc(Cl)cc(c1)C(=O)NC(=O)NC1CN2CCC1CC2
Show InChI InChI=1S/C15H17Cl2N3O2.ClH/c16-11-5-10(6-12(17)7-11)14(21)19-15(22)18-13-8-20-3-1-9(13)2-4-20;/h5-7,9,13H,1-4,8H2,(H2,18,19,21,22);1H
PDB

UniProtKB/SwissProt

GoogleScholar
AffyNet 
CHEMBL
PC cid
PC sid
UniChem
Article
PubMed
n/an/an/a 200n/an/an/an/an/a



Wyeth Research

Curated by ChEMBL


Assay Description
In vitro antagonism of the 5-HT-3 receptor determined by inhibition of 5-HT-induced depolarization of the isolated rat vagus nerve.


J Med Chem 35: 1515-20 (1992)


Article DOI: 10.1021/jm00087a003
BindingDB Entry DOI: 10.7270/Q24B32SK
More data for this
Ligand-Target Pair