BDBM50457775 CHEMBL451902::Robustaflavone-4''-Methyl Ether

SMILES COc1ccc(cc1-c1c(O)cc2oc(cc(=O)c2c1O)-c1ccc(O)cc1)-c1cc(=O)c2c(O)cc(O)cc2o1

InChI Key InChIKey=ZBOKFHZIWKIWRZ-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50457775   

Target72 kDa type IV collagenase(Homo sapiens (Human))
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50457775(CHEMBL451902 | Robustaflavone-4''-Methyl Ether)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human MMP2 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAmyloid-beta precursor protein(Homo sapiens (Human))
Meiji Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM50457775(CHEMBL451902 | Robustaflavone-4''-Methyl Ether)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of human amyloid beta (1 to 40) assessed as reduction in aggregation measured after 24 hrs by ThT fluorescence assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50457775(CHEMBL451902 | Robustaflavone-4''-Methyl Ether)
Affinity DataIC50:  2.61E+4nMAssay Description:Inhibition of recombinant human MMP9 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Guangxi Normal University

Curated by ChEMBL
LigandPNGBDBM50457775(CHEMBL451902 | Robustaflavone-4''-Methyl Ether)
Affinity DataIC50:  3.73E+4nMAssay Description:Inhibition of recombinant human MMP3 preincubated for 30 mins followed by McaPro-Leu-Gly-Leu-Dpa-Ala-Arg-NH2 substrate addition measured by fluoresce...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed