BDBM50461744 CHEMBL4227124

SMILES CCn1c(Sc2cccc(OC)c2)c(C)c2c(N)nc(N)nc12

InChI Key InChIKey=ULDSMDKWSKBCEI-UHFFFAOYSA-N

Data  2 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50461744   

TargetDihydrofolate reductase(Pneumocystis jirovecii)
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50461744(CHEMBL4227124)
Affinity DataIC50:  35nMAssay Description:Inhibition of Pneumocystis jirovecii recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetDihydrofolate reductase(Homo sapiens (Human))
Duquesne University

Curated by ChEMBL
LigandPNGBDBM50461744(CHEMBL4227124)
Affinity DataIC50:  511nMAssay Description:Inhibition of human recombinant DHFR expressed in Escherichia coli Rosetta Gami B (DE3) competent cells using DHFA as substrate and NADPHMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB