BindingDB BDBM50463484 CHEMBL4248525

BDBM50463484 CHEMBL4248525

SMILES CN1CCN(CCCOc2cccc(CC(=O)Nc3nc(cs3)-c3c[nH]c4ncccc34)c2)CC1

InChI Key InChIKey=KWQRIWDMNAKJAF-UHFFFAOYSA-N

Data 70 KI 3 IC50

PDB links: 1 PDB ID matches this monomer.

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 73 hits for monomerid = 50463484

Rho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: <1nMAssay Description:Inhibition of ROCK1 (6 to 553 residues) (unknown origin) using Lys-Lys-Arg-Asn-Arg-Thr-Leu-Ser-Val as substrate in presence of ATP by spectrophotomet...More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Rho-associated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: 6nMAssay Description:Inhibition of ROCK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed PDB

3D Structure (crystal)

Citron Rho-interacting kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: 660nMAssay Description:Inhibition of CIT (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Receptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: 910nMAssay Description:Inhibition of FLT3 (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ribosomal protein S6 kinase alpha-5(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+3nMAssay Description:Inhibition of MSK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Aurora kinase C(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+3nMAssay Description:Inhibition of AurC (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Aurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+3nMAssay Description:Inhibition of AurB (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Aurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+3nMAssay Description:Inhibition of AurA (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Cyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of CDK5/p35 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Angiopoietin-1 receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of TIE2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ephrin type-B receptor 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of EphB4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Calcium/calmodulin-dependent protein kinase type II subunit beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of CamK2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Lck(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of LCK (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Fyn(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of FYN (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase Sgk1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of SGK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Casein kinase I isoform alpha(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of CK1 (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of CDK1/CycB (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Ribosomal protein S6 kinase alpha-2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >2.00E+3nMAssay Description:Inhibition of RSK3 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Glycogen synthase kinase-3 beta(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: 2.10E+3nMAssay Description:Inhibition of GSK3beta (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of TAK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of Erk2 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Hepatocyte growth factor receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of MET (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of CDK2/CycA (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of PI3Kgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase kinase kinase 8(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of COT (unknown origin)More data for this Ligand-Target Pair

PDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase SYK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of SYK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of KDR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Interleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of IRAK4 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 14(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of p38alpha (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Proto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of SRC (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 10(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of JNK3 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase PLK1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of PLK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Protein kinase C gamma type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >4.00E+3nMAssay Description:Inhibition of PKCgamma (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase JAK2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: 4.40E+3nMAssay Description:Inhibition of JAK2 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase JAK3(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: 4.80E+3nMAssay Description:Inhibition of JAK3 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Epidermal growth factor receptor(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of EGFR (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Focal adhesion kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of FAK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 7(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of MKK7 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Protein kinase C iota type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of PKCiota (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

DNA-dependent protein kinase catalytic subunit(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of DNAPK (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway KEGG
UniProtKB/SwissProt
DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of ITK (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

RAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of RAFc (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Sphingosine kinase 1(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of SphK1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

RAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of Akt1 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of ATR (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Blk(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of Blk (unknown origin)More data for this Ligand-Target Pair

Reactome pathway KEGG
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Mitogen-activated protein kinase 8(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of JNK1 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB NCI pathway Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Tyrosine-protein kinase Lyn(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of LYN (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Dual specificity mitogen-activated protein kinase kinase 6(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of MKK6 (unknown origin)More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Serine/threonine-protein kinase Nek2(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL

PNG

BDBM50463484(CHEMBL4248525)

Ki: >1.00E+4nMAssay Description:Inhibition of NEK2 (unknown origin)More data for this Ligand-Target Pair

PDB Reactome pathway
UniProtKB/SwissProt
antibodypedia GoogleScholar

PC cid PC sid PDB

Details Article PubMed

Displayed 1 to 50 (of 73 total ) | Next | Last >>

Filter my 73 hits

Targets 71▿
- Rho-associated protein kinase 1 2
- Cytochrome P450 3A4 2
- Serine/threonine-protein kinase DCLK1 1
- Angiopoietin-1 receptor 1
- Protein kinase C epsilon type 1
- Hepatocyte growth factor receptor 1
- Mitogen-activated protein kinase 14 1
- Serine/threonine-protein kinase ATR 1
- Cyclin-dependent kinase 5 activator 1 1
- Protein kinase C iota type 1
- Glycogen synthase kinase-3 beta 1
- Receptor-type tyrosine-protein kinase FLT3 1
- Interleukin-1 receptor-associated kinase 4 1
- Calcium/calmodulin-dependent protein kinase type II subunit beta 1
- Serine/threonine-protein kinase Nek2 1
- Mitogen-activated protein kinase kinase kinase 8 1
- Mitogen-activated protein kinase kinase kinase 7 1
- Tyrosine-protein kinase ABL1 1
- Sphingosine kinase 1 1
- Serine/threonine-protein kinase PAK 2 1
- RAC-alpha serine/threonine-protein kinase 1
- Tyrosine-protein kinase JAK3 1
- Dual specificity mitogen-activated protein kinase kinase 1 1
- Tyrosine-protein kinase JAK2 1
- Dual specificity mitogen-activated protein kinase kinase 6 1
- Dual specificity mitogen-activated protein kinase kinase 7 1
- Ceramide kinase 1
- Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform 1
- Serine/threonine-protein kinase Sgk1 1
- Proto-oncogene tyrosine-protein kinase Src 1
- Tyrosine-protein kinase Fes/Fps 1
- Mitogen-activated protein kinase 1 1
- Serine/threonine-protein kinase 3 1
- Tyrosine-protein kinase Lck 1
- Mitogen-activated protein kinase 3 1
- Mitogen-activated protein kinase kinase kinase 14 1
- Tyrosine-protein kinase ITK/TSK 1
- DNA-dependent protein kinase catalytic subunit 1
- Tyrosine-protein kinase Blk 1
- Potassium voltage-gated channel subfamily H member 2 1
- Epidermal growth factor receptor 1
- Mitogen-activated protein kinase 8 1
- Tyrosine-protein kinase SYK 1
- Ribosomal protein S6 kinase alpha-2 1
- Cyclin-A2/Cyclin-dependent kinase 2 1
- Serine/threonine-protein kinase TBK1 1
- Cyclin-dependent kinase/G2/mitotic-specific cyclin- 1 1
- Aurora kinase B 1
- Vascular endothelial growth factor receptor 2 1
- Aurora kinase A 1
- Aurora kinase C 1
- Fibroblast growth factor receptor 3 1
- Serine/threonine-protein kinase PLK1 1
- Inhibitor of nuclear factor kappa-B kinase subunit beta 1
- Inhibitor of nuclear factor kappa-B kinase subunit alpha 1
- Mitogen-activated protein kinase 11 1
- Protein kinase C beta type 1
- Mitogen-activated protein kinase 10 1
- RAC-beta serine/threonine-protein kinase 1
- Casein kinase I isoform alpha 1
- Protein kinase C gamma type 1
- Tyrosine-protein kinase Fyn 1
- RAF proto-oncogene serine/threonine-protein kinase 1
- Citron Rho-interacting kinase 1
- Tyrosine-protein kinase Lyn 1
- Focal adhesion kinase 1 1
- Platelet-derived growth factor receptor alpha 1
- Ribosomal protein S6 kinase alpha-5 1
- Ephrin type-B receptor 4 1
- Serine/threonine-protein kinase Chk1 1
- MAP kinase-activated protein kinase 5 1
Publications 2▿
- Bioorg Med Chem Lett 28: 2622-2626 (2018) 70
- Bioorg Med Chem Lett 33: (2021) 3
Institutions 1▿
- Vertex Pharmaceuticals 73
Affinity: 1 to 3.0E+4 nM▿
- Ki 70
- IC50 3
- Affinity ≤ nM
Xtal structures: 1
Docked structures: 0
Catalog Cmpds: 0