BDBM50463743 CHEMBL4241370

SMILES CC(C)(CCCCC(=O)NO)Nc1c(Nc2ccc(cc2)C(F)(F)F)c(=O)c1=O

InChI Key InChIKey=RHUMXXCHLQENCI-UHFFFAOYSA-N

Data  16 KI

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 16 hits for monomerid = 50463743   

TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  0.270nMAssay Description:Inhibition of human recombinant HDAC1 using Fluor de Lys as substrate after 2 hrs by fluorescence methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  1nMAssay Description:Inhibition of human recombinant HDAC1 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolyamine deacetylase HDAC10(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant HDAC10 using fluorogenic HDAC substrate after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 3(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant HDAC3 using fluorogenic HDAC substrate after 10 mins by spectrophotometric methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 11(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  21nMAssay Description:Inhibition of human recombinant HDAC11 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 2(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  23nMAssay Description:Inhibition of human recombinant HDAC2 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 8(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  110nMAssay Description:Inhibition of human recombinant HDAC8 using fluorogenic HDAC substrate after 15 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 6(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  130nMAssay Description:Inhibition of human recombinant HDAC6 using fluorogenic HDAC substrate after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 5(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  360nMAssay Description:Inhibition of human recombinant HDAC5 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 7(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  1.70E+3nMAssay Description:Inhibition of human recombinant HDAC7 using fluorogenic HDAC substrate class 2a after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of human recombinant HDAC4 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-2(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT2 using fluoro-lysine sirtuin 2 deacetylase substrate after 60 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-7(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of SIRT7 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 9(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant HDAC9 using fluorogenic HDAC substrate class 2a after 30 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-3, mitochondrial(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT3 using fluoro-lysine sirtuin 2 deacetylase substrate after 45 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNAD-dependent protein deacetylase sirtuin-1(Homo sapiens (Human))
Nestle Skin Health R&D

Curated by ChEMBL
LigandPNGBDBM50463743(CHEMBL4241370)
Affinity DataKi: >1.00E+4nMAssay Description:Inhibition of human recombinant SIRT1 using fluorogenic HDAC substrate after 20 mins by fluorimetrc methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed