BDBM504686 (S)-5-(3-(pyridin-3- yl)-1,2,4-oxadiazol- 5-yl)-1-(4-(5- (trifluoromethyl)- 1,2,4-oxadiazol-3- yl)phenyl) pyrrolidin-2-one::US11066396, Example 113

SMILES FC(F)(F)c1nc(no1)-c1ccc(cc1)N1[C@@H](CCC1=O)c1nc(no1)-c1cccnc1

InChI Key InChIKey=WYVJKTWSDLDAAE-AWEZNQCLSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504686   

TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504686((S)-5-(3-(pyridin-3- yl)-1,2,4-oxadiazol- 5-yl)-1-...)
Affinity DataIC50:  7.20nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 8(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504686((S)-5-(3-(pyridin-3- yl)-1,2,4-oxadiazol- 5-yl)-1-...)
Affinity DataIC50:  410nMAssay Description:HDAC8 reagents: HDAC8 was purchased from Enzo Life Sciences [catalog #BML-SE145]. Assays were performed with buffer containing 20 mM HEPES, pH 8.0 [B...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504686((S)-5-(3-(pyridin-3- yl)-1,2,4-oxadiazol- 5-yl)-1-...)
Affinity DataIC50:  130nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent