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BDBM50477279 CHEMBL393730

SMILES: CC(Cl)(Cl)C(N\C(Nc1ccc(nc1)C(F)(F)F)=N\C#N)NC(=O)c1cc(F)cc(F)c1

InChI Key: InChIKey=AKRCFPVGGYKXJI-UHFFFAOYSA-N

Data: 1 EC50

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 50477279   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Sulfonylurea receptor 2, Kir6.2


(Homo sapiens (Human))
BDBM50477279
PNG
(CHEMBL393730)
Show SMILES CC(Cl)(Cl)C(N\C(Nc1ccc(nc1)C(F)(F)F)=N\C#N)NC(=O)c1cc(F)cc(F)c1
Show InChI InChI=1S/C18H13Cl2F5N6O/c1-17(19,20)15(30-14(32)9-4-10(21)6-11(22)5-9)31-16(28-8-26)29-12-2-3-13(27-7-12)18(23,24)25/h2-7,15H,1H3,(H,30,32)(H2,28,29,31)
PDB

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PC cid
PC sid
UniChem
Article
PubMed
n/an/an/an/a 1.18E+3n/an/an/an/a



Abbott Laboratories

Curated by ChEMBL


Assay Description
Channel opening activity at human bladder Kir6.2 channel containing SUR2B expressed in L cells by FLIPR assay


J Med Chem 50: 6265-73 (2007)


Article DOI: 10.1021/jm7010194
BindingDB Entry DOI: 10.7270/Q2VM4G2S
More data for this
Ligand-Target Pair