BDBM504874 8-fluoro- 2-({3- fluoro-4-[5- (trifluoro- methyl)- 1,2,4-oxa- diazol-3- yl]phenyl} methoxy) quinoline::US11066396, Example 282

SMILES Fc1cc(COc2ccc3cccc(F)c3n2)ccc1-c1noc(n1)C(F)(F)F

InChI Key InChIKey=GXKNPRJNDFSXAO-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 504874   

TargetHistone deacetylase 6(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504874(8-fluoro- 2-({3- fluoro-4-[5- (trifluoro- methyl)-...)
Affinity DataIC50:  16nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 5(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504874(8-fluoro- 2-({3- fluoro-4-[5- (trifluoro- methyl)-...)
Affinity DataIC50:  7nMAssay Description:HDAC5 reagents: N-terminal GST tagged HDAC5 was purchased from BPS Bioscience [catalog #50045]. Assays were performed with buffer containing 20 mM HE...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistone deacetylase 1(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM504874(8-fluoro- 2-({3- fluoro-4-[5- (trifluoro- methyl)-...)
Affinity DataIC50:  720nMAssay Description:HDAC1 and 6 reagents: FLAG-tagged HDACs 1 and 6 were prepared in-house by protein expression in HEK293F cells followed by anti-FLAG affinity purifica...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent