BDBM50500359 CHEMBL3747611::US11066363, Compound 13

SMILES CCc1cc2C(=O)c3c([nH]c4cc(ccc34)C#N)C(C)(C)c2cc1-c1cnn[nH]1

InChI Key InChIKey=QKYONSSKLFQUAK-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 50500359   

TargetALK tyrosine kinase receptor/Echinoderm microtubule-associated protein-like 4(Homo sapiens (Human))
Dana-Farber Cancer Institute

Curated by ChEMBL
LigandPNGBDBM50500359(CHEMBL3747611 | US11066363, Compound 13)
Affinity DataIC50:  115nMAssay Description:Inhibition of wild type EML4-ALK (unknown origin) expressed in mouse Ba/F3 cells assessed as cell viability after 72 hrs by MTS assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSRSF protein kinase 2(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50500359(CHEMBL3747611 | US11066363, Compound 13)
Affinity DataIC50:  7.46nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSRSF protein kinase 1(Homo sapiens (Human))
Dana-Farber Cancer Institute

US Patent
LigandPNGBDBM50500359(CHEMBL3747611 | US11066363, Compound 13)
Affinity DataIC50:  0.884nMAssay Description:SRPK1 Inhibitory Activities of the Compounds.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent