BDBM50502737 CHEMBL4441283::US11065231, Example 58

SMILES COc1cc2nn(cc2cc1NC(=O)c1cccc(n1)C(F)(F)F)C1CCN(CCOCCOc2ccc3C(=O)N(C4CCC(=O)NC4=O)C(=O)c3c2)CC1

InChI Key InChIKey=XXKSDGIIEAJWCB-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
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Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50502737   

TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50502737(CHEMBL4441283 | US11065231, Example 58)
Affinity DataIC50: <30nMAssay Description:A Z′-Lyte assay based on a fluorescence resonance energy transfer (FRET) readout was developed for measuring IRAK4-dependent phosphorylation of...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Arvinas Operations

US Patent
LigandPNGBDBM50502737(CHEMBL4441283 | US11065231, Example 58)
Affinity DataIC50: <30nMAssay Description:Inhibition of N-terminal GST-tagged human IRAK4 (2 to end residues) expressed in baculovirus infected Sf9 cells using Ser/Thr 7 peptide as substrate ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed