BDBM50504978 CHEMBL4527824

SMILES [H][C@]12C[C@H](O)[C@]([H])(C1)Nc1c(C(N)=O)c(nn1C2)-c1ccc2scnc2c1

InChI Key InChIKey=IYLHBITVRJLWLH-QRTLGDNMSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 50504978   

LigandPNGBDBM50504978(CHEMBL4527824)
Affinity DataIC50:  30nMAssay Description:Inhibition of full length FLAG/His-tagged RIPK2 (unknown origin) expressed in baculovirus expression system after 10 mins by fluorescent polarization...More data for this Ligand-Target Pair
LigandPNGBDBM50504978(CHEMBL4527824)
Affinity DataIC50:  50nMAssay Description:Inhibition of RIPK2 in MDP-stimulated human whole blood assessed as TNF-alpha level preincubated for 30 mins followed by MDP stimulation and measured...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50504978(CHEMBL4527824)
Affinity DataIC50:  3.16E+4nMAssay Description:Inhibition of full length His-Tev-tagged LCK (unknown origin) expressed in baculovirus expression system using Tamra-p34cdc2-derived peptide as subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50504978(CHEMBL4527824)
Affinity DataIC50:  7.94E+3nMAssay Description:Inhibition of GST-6His-tagged VEGFR2 (unknown origin) using biotin-aminohexyl-EEEEYFELVAKKKK-NH2 peptide as substrate after 90 mins by HTRF assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTGF-beta receptor type-1(Human)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50504978(CHEMBL4527824)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of full length GST-tagged ALK5 (unknown origin) expressed in baculovirus expression system incubated for 2 mins by fluorescent polarizatio...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed