BDBM50505258 CHEMBL4588728

SMILES CSCC[C@@H]1NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CCCCN)NC(=O)[C@@H]2CSSC[C@@H]3NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@H](Cc4ccccc4)NC(=O)[C@H](CCSC)NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCNC(N)=N)NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](CSSC[C@H](NC(=O)[C@H](Cc4ccc(O)cc4)NC(=O)[C@H](CCCCN)NC1=O)C(=O)N[C@@H](C)C(=O)N[C@@H](Cc1c[nH]c4ccccc14)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CCC(O)=O)NC3=O)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](Cc1cnc[nH]1)C(=O)N[C@@H](CC(C)C)C(=O)NCC(=O)N2)NC(=O)[C@@H](N)CC(O)=O

InChI Key InChIKey=DFBDAHMZXJYZJG-AALCJKKVSA-N

Data  10 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 10 hits for monomerid = 50505258   

TargetSodium channel protein type 7 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 2 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  120nMAssay Description:Inhibition of human Nav1.2 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 4 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  140nMAssay Description:Inhibition of human Nav1.4 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Mus musculus)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  4.40nMAssay Description:Inhibition of mouse Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 10 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  5.00E+4nMAssay Description:Inhibition of human Nav1.8 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 8 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  130nMAssay Description:Inhibition of human Nav1.6 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 1 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  37nMAssay Description:Inhibition of human Nav1.1 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 3 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  210nMAssay Description:Inhibition of human Nav1.3 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 5 subunit alpha(Homo sapiens (Human))
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  800nMAssay Description:Inhibition of human Nav1.5 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSodium channel protein type 9 subunit alpha(Rattus norvegicus)
Siteone Therapeutics

Curated by ChEMBL
LigandPNGBDBM50505258(CHEMBL4588728)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of rat Nav1.7 expressed in HEK293 cells by electrophysiology assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed