BDBM524905 BDBM50505947::US11168095, Example 160
SMILES Fc1ccc2OCCCCn3cnnc3-c3cccc(NC(=O)c2c1)n3
InChI Key InChIKey=WZAVJOVXKFCADI-UHFFFAOYSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 524905
Affinity DataIC50: 17nMAssay Description:Inhibition of human ASK1 using myelin basic protein substrate pre-incubated for 20 mins before [33P]-ATP addition and measured after 2 hrs by filter-...More data for this Ligand-Target Pair
Affinity DataIC50: <100nMAssay Description:Table 1: Briefly, 20 μL aliquots of a 1.5× stock of ASK1, STK Substrate 3 and Assay Buffer were distributed in the wells of a white 384 well Opt...More data for this Ligand-Target Pair
Affinity DataKd: 300nMAssay Description:The binding of compounds to ASK1 were determined using DiscoverX's proprietary technology. KINOMEscan™ is based on a competition binding assay th...More data for this Ligand-Target Pair
Affinity DataIC50: 658nMAssay Description:Inhibition of V5 tagged human ASK1 expressed in HEK-293T cells assessed as reduction in T838 autophosphorylation incubated for 1 hrMore data for this Ligand-Target Pair