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BDBM505099 US11066404, Example 2

SMILES: CC1(C)Cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2N(C2CCCC2)C1=O

InChI Key: InChIKey=KAXGLYVSAHPKEK-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 505099   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
CDK2/CycE


(Homo sapiens (Human))
BDBM505099
PNG
(US11066404, Example 2)
Show SMILES CC1(C)Cc2cnc(NC3CCN(CC3)S(C)(=O)=O)nc2N(C2CCCC2)C1=O
Show InChI InChI=1S/C20H31N5O3S/c1-20(2)12-14-13-21-19(22-15-8-10-24(11-9-15)29(3,27)28)23-17(14)25(18(20)26)16-6-4-5-7-16/h13,15-16H,4-12H2,1-3H3,(H,21,22,23)
PDB

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US Patent
n/an/a<10n/an/an/an/an/an/a



Incyte Corporation

US Patent


Assay Description
CDK2/Cyclin E1 enzyme activity assays utilize full-length human CDK2 co-expressed as N-terminal GST-tagged protein with FLAG-Cyclin E1 in a baculovir...


US Patent US11066404 (2021)

More data for this
Ligand-Target Pair