BDBM50522804 CHEMBL4437751

SMILES Fc1ccc(cn1)-c1ccc2nc(sc2c1)C(C(=O)NCC(=O)NC1CC1)S(=O)(=O)Cc1ccccc1

InChI Key InChIKey=CLHZIKCWBUWLQU-UHFFFAOYSA-N

Data  4 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50522804   

TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50522804(CHEMBL4437751)
Affinity DataIC50:  65nMAssay Description:Inhibition of human endothelial lipase using D31-POPC-HDL as substrate incubated for 2 hrs in presence of human serum by LC/MS analysisMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50522804(CHEMBL4437751)
Affinity DataIC50:  25nMAssay Description:Inhibition of human endothelial lipase derived from human HT1080 cell conditioned media using PED-A1 as substrate incubated for 20 mins and measured ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEndothelial lipase(Mus musculus (Mouse))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50522804(CHEMBL4437751)
Affinity DataIC50:  94nMAssay Description:Inhibition of mouse endothelial lipase expressed in HEK293F cells using D31-POPC-HDL as substrate incubated for 2 hrs in presence of mouse plasma by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatic triacylglycerol lipase(Homo sapiens (Human))
Bristol-Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50522804(CHEMBL4437751)
Affinity DataIC50:  7nMAssay Description:Inhibition of human hepatic lipase expressed in African green monkey COS7 cells using PED-A1 as substrate incubated for 20 mins and measured every 20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed