BDBM50524862 CHEMBL4475680
SMILES O[C@@]1(CCN(C1=O)c1ccc2NC(=O)CCc2c1)C(=O)NCc1cc(F)cc(Cl)c1
InChI Key InChIKey=RMWSKRBLJAUOOY-NRFANRHFSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 10 hits for monomerid = 50524862
Affinity DataKi: 0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataKi: 0.160nMAssay Description:Inhibition of 5-[(S)-3-(3-Chloro-5-fluoro-benzylcarbamoyl)-3-hydroxy-2-oxopyrrolidin-1-yl]-1H-indole-2-carboxylic Acid (3-Amino-propyl)-amide-Dy647 b...More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 75nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and MnCl2 as co-facor preincubated fo...More data for this Ligand-Target Pair
Affinity DataIC50: 15nMAssay Description:Inhibition of MetAP2 in HUVEC assessed as reduction in viability incubated for 3 days by CyQUANT Direct Cell proliferation assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of N-terminal MetAP1 (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and cobalt as co-facor preincubated f...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMAssay Description:Inhibition of recombinant human N-terminal His-tagged MetAP2 (2 to 478 residues) using Met-Ala-Ser as substrate and manganese as co-facor preincubate...More data for this Ligand-Target Pair