BDBM50526409 CHEMBL4522365

SMILES CCc1cc(O)cc2c(\C=N\NC(=N)NCCc3ccc(Cl)cc3)c[nH]c12

InChI Key InChIKey=NQWXHRRWWPCDAJ-BRJLIKDPSA-N

Data  1 KI  8 EC50

PDB links: 1 PDB ID matches this monomer.

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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 9 hits for monomerid = 50526409   

TargetRelaxin-3 receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataKi:  274nMAssay Description:Displacement of [125I]R3/I5 from human RXFP3 expressed in human CHO-K1 cells incubated for 1 hr by microplate scintillation counting analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRelaxin-3 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  11nMAssay Description:Agonist activity at human RXFP4 expressed in CHOK1 cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 3 hrs by scintillation cou...More data for this Ligand-Target Pair
TargetRelaxin-3 receptor 1/2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  4.90E+3nMAssay Description:Agonist activity at human RXFP3/4 in human U2OS cells assessed as induction of beta-arrestin recruitment incubated for 1 hr by chemiluminescence base...More data for this Ligand-Target Pair
TargetRelaxin-3 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  2nMAssay Description:Agonist activity at human RXFP4 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated ...More data for this Ligand-Target Pair
TargetRelaxin-3 receptor 2(Human)
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  0.800nMAssay Description:Agonist activity at human RXFP4 expressed in human CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs ...More data for this Ligand-Target Pair
TargetRelaxin-3 receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  18nMAssay Description:Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as inhibition of forskolin-induced cAMP accumulation measured after 1.5 hrs ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRelaxin-3 receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  22nMAssay Description:Agonist activity at human RXFP3 expressed in human CHO-K1 cells assessed as beta arrestin-2 recruitment measured after 4 hrs by beta-galactosidase ba...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRelaxin-3 receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  119nMAssay Description:Agonist activity at human RXFP3 expressed in CHOK1 cell membranes assessed as stimulation of [35S]-GTPgammaS binding after 3 hrs by scintillation cou...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRelaxin-3 receptor 1(Human)
Research Triangle Institute

Curated by ChEMBL
LigandPNGBDBM50526409(CHEMBL4522365)
Affinity DataEC50:  82nMAssay Description:Agonist activity at human RXFP3 expressed in CHOK1 cells assessed as inhibition of forskolin-stimulated intracellular cAMP accumulation preincubated ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed