BDBM50536675 CHEMBL4569508

SMILES FC(F)(F)CNC(=O)c1cc(cs1)-c1cnn2cc(cnc12)-c1ccc(OCCN2CCCCC2)cc1

InChI Key InChIKey=QNABDSWBQJKBHK-UHFFFAOYSA-N

Data  100 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 100 hits for monomerid = 50536675   

TargetAurora kinase B(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  33nMAssay Description:Inhibition of full-length recombinant human His-tagged AURKB expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  57nMAssay Description:Inhibition of full-length recombinant human His-tagged CHEK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic KDR expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  380nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic NTRK3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PLK1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged PLK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-A receptor 3(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  180nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic EPHA3 expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human C-terminal His-tagged cytoplasmic IGF1R (960 to 1397 residues) expressed in baculovirus expression system by Z'-LYTE ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP kinase-activated protein kinase 5(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  9.60E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPKAPK5 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRibosomal protein S6 kinase alpha-3(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  260nMAssay Description:Inhibition of full-length recombinant human His-tagged RPS6KA3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase TBK1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of full-length recombinant human GST-tagged TBK1 expressed in insect cells by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMAP/microtubule affinity-regulating kinase 4(Mus musculus)
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  50nMAssay Description:Inhibition of MARK4 in mouse cortical neurons assessed as inhibition of okadaic acid-induced tau phosphorylation at S262 residue preincubated for 15 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-beta serine/threonine-protein kinase(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  2.30E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged AKT2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full-length recombinant human His-tagged AKT3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetActivin receptor type-1B(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  200nMAssay Description:Inhibition of recombinant human GST-tagged ALK4 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  410nMAssay Description:Inhibition of full-length recombinant human His-tagged BMX expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  550nMAssay Description:Inhibition of full-length recombinant human GST-tagged BRAF expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  290nMAssay Description:Inhibition of full-length recombinant human His-tagged BTK expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  12nMAssay Description:Inhibition of full-length recombinant human His-tagged CDK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 7(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  30nMAssay Description:Inhibition of full-length recombinant human His-tagged CDK7 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Chk2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  450nMAssay Description:Inhibition of full-length recombinant human His-tagged CHEK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity protein kinase CLK2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDeath-associated protein kinase 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human GST-tagged DAPK1 catalytic domain expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of full-length recombinant human GST-tagged DYRK1A expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEphrin type-B receptor 2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic EPHB2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  70nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic FGFR2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic FLT3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG protein-coupled receptor kinase 6(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  1.70E+4nMAssay Description:Inhibition of full-length recombinant human GST-tagged GRK6 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetGlycogen synthase kinase-3 alpha(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  360nMAssay Description:Inhibition of full-length human GST-tagged GSK3A expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of full-length recombinant human GST-tagged IKK-beta expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of full-length recombinant human GST-tagged IKK-epsilon expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50: <10nMAssay Description:Inhibition of recombinant human GST-tagged IRAK1 (194 to 712 residues) catalytic domain expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  26nMAssay Description:Inhibition of full-length recombinant human GST-tagged ITK expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK2 (809 to 1153 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  280nMAssay Description:Inhibition of recombinant human GST-tagged JAK3 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  19nMAssay Description:Inhibition of full-length recombinant human His-tagged LCK expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  1.20E+4nMAssay Description:Inhibition of recombinant human GST-tagged MAP3K8 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPK13 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 8(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPK8 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 9(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  850nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPK9 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMisshapen-like kinase 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  13nMAssay Description:Inhibition of recombinant human His-tagged MINK1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase 26(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  1.10E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged MST4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek2(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  1.60E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged NEK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase Nek6(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  8.80E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged NEK6 expressed in insect cells by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  310nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic NTRK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase PAK 1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  8.30E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged PAK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  3.70E+4nMAssay Description:Inhibition of recombinant human GST-tagged PASK catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  5.50E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged PIK3P110D/P85A expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase N1(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged PKN1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Merck And

Curated by ChEMBL
LigandPNGBDBM50536675(CHEMBL4569508)
Affinity DataIC50:  1.50E+4nMAssay Description:Inhibition of recombinant human His-tagged PRKACA catalytic domain expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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