BDBM50536681 CHEMBL4552628
SMILES Cc1sc(cc1-c1cnn2cc(Cl)cnc12)C(=O)N[C@@H]1[C@H](N)CCCC1(F)F
InChI Key InChIKey=NGFGTMFVWSDFPS-UKRRQHHQSA-N
Data 100 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 100 hits for monomerid = 50536681
Affinity DataIC50: 5nMAssay Description:Inhibition of full-length recombinant human GST-tagged MARK3 expressed in baculovirus expression system using biotinylated-Cdc25C peptide substrate m...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+4nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic KDR expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPK8 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic NTRK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetcAMP-dependent protein kinase catalytic subunit alpha(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of recombinant human His-tagged PRKACA catalytic domain expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged RPS6KB1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 200nMAssay Description:Inhibition of full-length recombinant human His-tagged CHEK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+4nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic EPHA8 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human C-terminal His-tagged cytoplasmic IGF1R (960 to 1397 residues) expressed in baculovirus expression system by Z'-LYTE ...More data for this Ligand-Target Pair
Affinity DataIC50: 1.00E+4nMAssay Description:Inhibition of recombinant human N-terminal GST-tagged cytoplasmic TYK2 (833 to 1187 residues) catalytic domain expressed in baculovirus expression sy...More data for this Ligand-Target Pair
Affinity DataIC50: 9.10E+3nMAssay Description:Inhibition of full-length human His-tagged ABL1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.40E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged AKT3 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged ALK4 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Target5'-AMP-activated protein kinase catalytic subunit alpha-1/subunit beta-1/subunit gamma-1(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 53nMAssay Description:Inhibition of full-length recombinant human GST and His-tagged AMPK alpha1/beta1/gamma1 expressed in baculovirus expression system by LanthaScreen as...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged BRAF expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged BTK expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetCalcium/calmodulin-dependent protein kinase type IV(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 2.90E+4nMAssay Description:Inhibition of full-length recombinant human GST-tagged CAMK4 expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 61nMAssay Description:Inhibition of full-length recombinant human GST and His-tagged CDK5/P25 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: <10nMAssay Description:Inhibition of full-length recombinant human His-tagged CDK7 expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of recombinant human GST-tagged CLK2 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 2.20E+4nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic CSF1R expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.80E+4nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic CSNK1A1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetDual specificity tyrosine-phosphorylation-regulated kinase 1A(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 130nMAssay Description:Inhibition of full-length recombinant human GST-tagged DYRK1A expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human His-tagged EGFR expressed in mammalian expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic ERBB2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of recombinant human His-tagged cytoplasmic FGFR2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 670nMAssay Description:Inhibition of full-length recombinant human GST-tagged GRK4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 110nMAssay Description:Inhibition of full-length human GST-tagged GSK3A expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 150nMAssay Description:Inhibition of full-length recombinant human His-tagged GSK3B expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetInhibitor of nuclear factor kappa-B kinase subunit epsilon(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 48nMAssay Description:Inhibition of full-length recombinant human GST-tagged IKK-epsilon expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic INSR (1011 to 1382 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3.00E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged IRAK4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.30E+3nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK1 (866 to 1154 residues) catalytic domain expressed in baculovirus expression system by Z'-...More data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged cytoplasmic JAK2 (809 to 1153 residues) expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 5.00E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged LCK expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetLeucine-rich repeat serine/threonine-protein kinase 2(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 62nMAssay Description:Inhibition of recombinant human GST-tagged LRRK2 catalytic domain expressed in baculovirus expression system by Adapta assayMore data for this Ligand-Target Pair
TargetDual specificity mitogen-activated protein kinase kinase 1(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 1.10E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAP2K1 expressed in baculovirus expression system by LanthaScreen assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+3nMAssay Description:Inhibition of full-length recombinant human GST-tagged MAPK1 expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full-length recombinant human GST-tagged MAPK14 alpha expressed in Escherichia coli by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4.40E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPK9 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full-length recombinant human His-tagged MAPKAPK5 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 140nMAssay Description:Inhibition of recombinant human His-tagged MINK1 catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30E+4nMAssay Description:Inhibition of full-length recombinant human His-tagged NEK2 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 480nMAssay Description:Inhibition of full-length recombinant human GST-tagged NEK4 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of full-length recombinant human GST-tagged NEK6 expressed in insect cells by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetPAS domain-containing serine/threonine-protein kinase(Homo sapiens (Human))
Merck And
Curated by ChEMBL
Merck And
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of recombinant human GST-tagged PASK catalytic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 330nMAssay Description:Inhibition of full-length recombinant human His-tagged PDK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.60E+3nMAssay Description:Inhibition of full-length recombinant human His-tagged PIM1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.70E+4nMAssay Description:Inhibition of full-length recombinant human GST-tagged PKN1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
Affinity DataIC50: >1.00E+5nMAssay Description:Inhibition of full-length recombinant human His-tagged PLK1 expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair