BDBM50538507 CHEMBL4640601
SMILES COc1ccc(cc1OC)-c1cnn2c(N)c(-c3ccccc3)c(OC3CCN(C)CC3)nc12
InChI Key InChIKey=YZNIHXUBUWEUCM-UHFFFAOYSA-N
Data 38 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 38 hits for monomerid = 50538507
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 37nMAssay Description:Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l...More data for this Ligand-Target Pair
TargetCoiled-coil domain-containing protein 6(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 95nMAssay Description:Inhibition of CCDC6/RET (unknown origin) transfected in human LC2/ad cells assessed as reduction in cell viability incubated for 6 days by CellTiter ...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 170nMAssay Description:Inhibition of RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 870nMAssay Description:Inhibition of BCR/ABL (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc...More data for this Ligand-Target Pair
TargetALK tyrosine kinase receptor/Nucleophosmin(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 8.30E+3nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 520nMAssay Description:Inhibition of BLK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of BMX (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >5.60E+3nMAssay Description:Inhibition of FGFR1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.70E+3nMAssay Description:Inhibition of FGFR2 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >9.80E+3nMAssay Description:Inhibition of FGFR3 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of FGFR4 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 98nMAssay Description:Inhibition of FGR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of FLT1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.70E+3nMAssay Description:Inhibition of FLT3 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 400nMAssay Description:Inhibition of FMS (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of IGF1R (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
TargetInsulin receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of INSR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.30E+3nMAssay Description:Inhibition of JAK2 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 910nMAssay Description:Inhibition of KIT (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 110nMAssay Description:Inhibition of LCK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 410nMAssay Description:Inhibition of LYN (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of MER (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of MET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 93nMAssay Description:Inhibition of PDGFRalpha (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-...More data for this Ligand-Target Pair
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 100nMAssay Description:Inhibition of PDGFRbeta (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l...More data for this Ligand-Target Pair
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of RON (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of ROS (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 120nMAssay Description:Inhibition of SRC (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 7.60E+3nMAssay Description:Inhibition of SYK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor Tie-1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of TIE1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of TRKA (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of TRKB (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of TRKC (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of TYRO3 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of ZAP70 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
TargetTranscription factor ETV6/Vascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.40E+3nMAssay Description:Inhibition of TEL/KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc...More data for this Ligand-Target Pair
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.80E+3nMAssay Description:Inhibition of KIF5B-RET V804M mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs b...More data for this Ligand-Target Pair