BDBM50538508 CHEMBL4634073

SMILES COC(=O)Nc1ccc(cc1)-c1c(OC2CCN(C)CC2)nc2c(cnn2c1N)-c1ccc(OC)c(OC)c1

InChI Key InChIKey=UKYJKXMPIDEQFF-UHFFFAOYSA-N

Data  36 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 36 hits for monomerid = 50538508   

TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  6nMAssay Description:Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ZAP-70(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  9.10E+3nMAssay Description:Inhibition of ZAP70 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  6nMAssay Description:Inhibition of RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBreakpoint cluster region protein/Tyrosine-protein kinase ABL1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  5.10E+3nMAssay Description:Inhibition of BCR/ABL (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetALK tyrosine kinase receptor/Nucleophosmin(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of NPM/ALK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-luc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  230nMAssay Description:Inhibition of BLK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50: >7.40E+3nMAssay Description:Inhibition of BMX (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  10nMAssay Description:Inhibition of FGFR1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  8nMAssay Description:Inhibition of FGFR2 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 3(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  430nMAssay Description:Inhibition of FGFR3 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFibroblast growth factor receptor 4(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  35nMAssay Description:Inhibition of FGFR4 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Fgr(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  440nMAssay Description:Inhibition of FGR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of FLT1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein kinase FLT3(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  3.40E+3nMAssay Description:Inhibition of FLT3 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage colony-stimulating factor 1 receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  82nMAssay Description:Inhibition of FMS (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50: >7.50E+3nMAssay Description:Inhibition of IGF1R (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50: >9.10E+3nMAssay Description:Inhibition of INSR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  84nMAssay Description:Inhibition of JAK2 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  26nMAssay Description:Inhibition of KDR (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  20nMAssay Description:Inhibition of KIT (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lck(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  2.40E+3nMAssay Description:Inhibition of LCK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Lyn(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  67nMAssay Description:Inhibition of LYN (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Mer(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  86nMAssay Description:Inhibition of MER (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHepatocyte growth factor receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50: >1.10E+4nMAssay Description:Inhibition of MET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  17nMAssay Description:Inhibition of PDGFRalpha (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor beta(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  22nMAssay Description:Inhibition of PDGFRbeta (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMacrophage-stimulating protein receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  6.00E+3nMAssay Description:Inhibition of RON (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase ROS(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  5.50E+3nMAssay Description:Inhibition of ROS (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  5.00E+3nMAssay Description:Inhibition of SRC (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of SYK (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucifer...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor Tie-1(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of TIE1 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  2.80E+3nMAssay Description:Inhibition of TRKA (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  2.10E+3nMAssay Description:Inhibition of TRKB (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNT-3 growth factor receptor(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  1.40E+3nMAssay Description:Inhibition of TRKC (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucife...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase receptor TYRO3(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  3.70E+3nMAssay Description:Inhibition of TYRO3 (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-lucif...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation

Curated by ChEMBL
LigandPNGBDBM50538508(CHEMBL4634073)
Affinity DataIC50:  19nMAssay Description:Inhibition of KIF5B-RET V804M mutant (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs b...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed