BDBM50540349 CHEMBL4648675::US11427590, Entry 9

SMILES CSc1ccc(cc1)-c1c(C)nc2c(cc(C)nn12)N1CC[C@H](C1)NC(C)=O

InChI Key InChIKey=MKNLNYPXJFOEJD-QGZVFWFLSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50540349   

TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
The Johns Hopkins University

US Patent
LigandPNGBDBM50540349(CHEMBL4648675 | US11427590, Entry 9)
Affinity DataIC50:  200nMAssay Description:The fluorescence based assay to monitor the activity of human nSMase2 in the presence or absence of potential inhibitors has been described recently....More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSphingomyelin phosphodiesterase 3(Homo sapiens)
The Johns Hopkins University

US Patent
LigandPNGBDBM50540349(CHEMBL4648675 | US11427590, Entry 9)
Affinity DataIC50:  200nMAssay Description:Inhibition of human recombinant full-length nSMase expressed in HEK293 cells using sphingomyelin as substrate measured after 1 hr by alkaline phospha...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed