BDBM50559821 CHEMBL4781596

SMILES: COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1

InChI Key: InChIKey=OQDKZJYHCUFKRI-LRDDRELGSA-N

Data: 1 IC50  3 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 50559821   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
N-formyl peptide receptor 2 (Homo sapiens (Human))	BDBM50559821 (CHEMBL4781596) Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 Show InChI InChI=1S/C18H16F3N3O3/c1-27-11-6-13(20)15(14(21)7-11)12-8-22-17(25)16(12)24-18(26)23-10-4-2-9(19)3-5-10/h2-7,12,16H,8H2,1H3,(H,22,25)(H2,23,24,26)/t12-,16-/m0/s1	PDB NCI pathway Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	0.140	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Agonist activity at human FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...				J Med Chem 63: 9003-9019 (2020)
					More data for this Ligand-Target Pair
Cytochrome P450 3A4 (Homo sapiens (Human))	BDBM50559821 (CHEMBL4781596) Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 Show InChI InChI=1S/C18H16F3N3O3/c1-27-11-6-13(20)15(14(21)7-11)12-8-22-17(25)16(12)24-18(26)23-10-4-2-9(19)3-5-10/h2-7,12,16H,8H2,1H3,(H,22,25)(H2,23,24,26)/t12-,16-/m0/s1	PDB MMDB Reactome pathway KEGG UniProtKB/SwissProt UniProtKB/TrEMBL DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	>2.00E+4	n/a	n/a	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Inhibition of recombinant human CYP3A4				J Med Chem 63: 9003-9019 (2020)
					More data for this Ligand-Target Pair
Formyl peptide receptor 2 (Mus musculus)	BDBM50559821 (CHEMBL4781596) Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 Show InChI InChI=1S/C18H16F3N3O3/c1-27-11-6-13(20)15(14(21)7-11)12-8-22-17(25)16(12)24-18(26)23-10-4-2-9(19)3-5-10/h2-7,12,16H,8H2,1H3,(H,22,25)(H2,23,24,26)/t12-,16-/m0/s1	KEGG UniProtKB/SwissProt GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	1.5	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Agonist activity at mouse FPR2 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...				J Med Chem 63: 9003-9019 (2020)
					More data for this Ligand-Target Pair
fMet-Leu-Phe receptor (Homo sapiens (Human))	BDBM50559821 (CHEMBL4781596) Show SMILES COc1cc(F)c([C@@H]2CNC(=O)[C@H]2NC(=O)Nc2ccc(F)cc2)c(F)c1 Show InChI InChI=1S/C18H16F3N3O3/c1-27-11-6-13(20)15(14(21)7-11)12-8-22-17(25)16(12)24-18(26)23-10-4-2-9(19)3-5-10/h2-7,12,16H,8H2,1H3,(H,22,25)(H2,23,24,26)/t12-,16-/m0/s1	PDB Reactome pathway KEGG UniProtKB/SwissProt DrugBank antibodypedia GoogleScholar	UniChem	PubMed	n/a	n/a	n/a	n/a	280	n/a	n/a	n/a	n/a
Kyorin Pharmaceutical Co. Ltd. Curated by ChEMBL					Assay Description Agonist activity at human FPR1 expressed in HEK 293 cells co-expressing Galpha15 measured every 1.5 sec for 80 sec by Fluo-4 NW staining based scanni...				J Med Chem 63: 9003-9019 (2020)
					More data for this Ligand-Target Pair