BDBM50561924 CHEMBL4750775::US11236069, Example 6-29

SMILES OCCS(=O)(=O)Nc1ccc(C(=O)Nc2ccnc(c2)N2CCC(F)(F)CC2)c(c1)N1CCC2(CC2)CC1

InChI Key InChIKey=APYGLDGMCNWDQE-UHFFFAOYSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 50561924   

TargetKinesin-like protein KIF18A [1-467](Homo sapiens (Human))
Amgen

US Patent
LigandPNGBDBM50561924(CHEMBL4750775 | US11236069, Example 6-29)
Affinity DataIC50:  17nMAssay Description:Microtubule-stimulated ATPase activity assay is used to measure KIF18A enzyme activity after treatment with compound. Compounds were 2-fold serially ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetKinesin-like protein KIF18A(Homo sapiens)
Smith, Gambrell & Russell

Curated by ChEMBL
LigandPNGBDBM50561924(CHEMBL4750775 | US11236069, Example 6-29)
Affinity DataIC50:  17nMAssay Description:Inhibition of recombinant human His-tagged KIF18A (1 to 467 residues) expressed in baculovirus expression system assessed as inhibition of microtubul...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed