BDBM506233 (S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3- triazol-4-yl)(2-methyl-1-oxo-1,2- dihydroisoquinolin-5-yl)methyl)amino)-4- ((3,3,3-trifluoro-2,2- dimethylpropyl)amino)quinoline- 3,8-dicarbonitrile::US11066414, Compound 883

SMILES Cn1ccc2c(cccc2c1=O)[C@H](Nc1cc(C#N)c2ncc(C#N)c(NCC(C)(C)C(F)(F)F)c2c1)C1=CN(NN1)C12CC(C1)C2

InChI Key InChIKey=RTUFPJIZOARNCR-ZAGPDIDGSA-N

Data  1 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 506233   

TargetEpidermal growth factor receptor(Homo sapiens (Human))
Gilead Sciences

US Patent
LigandPNGBDBM506233((S)-6-(((1-(bicyclo[1.1.1]pentan- 1-yl)-1H-1,2,3- ...)
Affinity DataIC50:  1nMAssay Description:EGFR activity was measured using KinEASE (Cisbio), a time-resolved fluorescence resonance energy transfer (TR-FRET) immunoassay. In this assay, EGFR-...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent