BDBM506428 US11045457, Example 28

SMILES CN1C[C@@H](NC(=O)C(C)(C)COc2ncccc2C(F)(F)F)[C@@H](C1)c1cnn(C)c1C

InChI Key InChIKey=GAHDIMDPQHFBBK-DOTOQJQBSA-N

Data  2 IC50  1 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 506428   

TargetSomatostatin receptor type 4(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506428(US11045457, Example 28)
Affinity DataEC50:  1.58nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506428(US11045457, Example 28)
Affinity DataIC50:  158nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR1 in membranes from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506428(US11045457, Example 28)
Affinity DataIC50:  20nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent