BDBM506539 US11045457, Example 139::US11045457, Example 177

SMILES C[C@@H]1C[C@H](CCN1C)NC(=O)C(C)(C)COc1ncccc1C(F)(F)F

InChI Key InChIKey=PAZHTQRFSKYTCX-OLZOCXBDSA-N

Data  2 IC50  2 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 4 hits for monomerid = 506539   

TargetSomatostatin receptor type 4(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506539(US11045457, Example 139 | US11045457, Example 177)
Affinity DataEC50:  12.6nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506539(US11045457, Example 139 | US11045457, Example 177)
Affinity DataEC50:  126nMAssay Description:This cell-based assay measures the ability of compounds to inhibit forskolin stimulated cAMP in CHO-K1 cells overexpressing SSTR4. CHO-K1 cells overe...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 1(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506539(US11045457, Example 139 | US11045457, Example 177)
Affinity DataIC50:  6.31E+3nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR1 in membranes from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSomatostatin receptor type 4(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM506539(US11045457, Example 139 | US11045457, Example 177)
Affinity DataIC50:  63.1nMAssay Description:This membrane-based assay measures the ability of compounds to competitively inhibit binding of I-125 labeled somatostatin to SSTR4 in membranes from...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent