BDBM507035 2-Amino-8-(1,4-dihydroquinazolin-2-yl)-N,N-dipropyl-3H-1-benzazepine-4-carboxamide::US11046671, Example 1

SMILES: CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1

InChI Key: InChIKey=YPFKRHIMKWNXDJ-UHFFFAOYSA-N

Data: 2 EC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 507035   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Toll-like receptor 7 (Homo sapiens (Human))	BDBM507035 (2-Amino-8-(1,4-dihydroquinazolin-2-yl)-N,N-dipropy...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C25H29N5O/c1-3-11-30(12-4-2)25(31)20-13-17-9-10-18(14-22(17)28-23(26)15-20)24-27-16-19-7-5-6-8-21(19)29-24/h5-10,13-14H,3-4,11-12,15-16H2,1-2H3,(H2,26,28)(H,27,29)	PDB Reactome pathway UniProtKB/SwissProt UniProtKB/TrEMBL antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	>1.00E+5	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair
Toll-like receptor 8 (Homo sapiens (Human))	BDBM507035 (2-Amino-8-(1,4-dihydroquinazolin-2-yl)-N,N-dipropy...) Show SMILES CCCN(CCC)C(=O)C1=Cc2ccc(cc2N=C(N)C1)C1=NCc2ccccc2N1 Show InChI InChI=1S/C25H29N5O/c1-3-11-30(12-4-2)25(31)20-13-17-9-10-18(14-22(17)28-23(26)15-20)24-27-16-19-7-5-6-8-21(19)29-24/h5-10,13-14H,3-4,11-12,15-16H2,1-2H3,(H2,26,28)(H,27,29)	PDB Reactome pathway UniProtKB/SwissProt antibodypedia GoogleScholar	PC cid PC sid UniChem	US Patent	n/a	n/a	n/a	n/a	3	n/a	n/a	n/a	n/a
Hoffmann-La Roche Inc. US Patent					Assay Description For TLR8 and TLR7 activity testing, HEK-Blue human TLR8 or TLR7 cells (Invivogen, San Diego, Calif., USA) are used, respectively. These cells are des...				US Patent US11046671 (2021)
					More data for this Ligand-Target Pair