BDBM507736 (R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenylquinazolin-2(1H)-one::US11046691, Compound 80::US11084798, Cpd No 80::US11130759, Cpd. No. 80

SMILES F[C@@H]1CCN(C1)c1nc(=O)n(-c2ccccc2)c2cc(Cl)ccc12

InChI Key InChIKey=GPTUSHRRTGGGTD-CYBMUJFWSA-N

Data  5 IC50

PDB links: 1 PDB ID matches this monomer.

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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 5 hits for monomerid = 507736   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507736((R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenyl...)
Affinity DataIC50: <200nMAssay Description:Materials:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Subst...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507736((R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenyl...)
Affinity DataIC50: <200nMAssay Description:5 μL of 3× final concentration test compounds in DMSO or DMSO were transferred to the appropriate wells of a microtiter plate and the plate was ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507736((R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenyl...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507736((R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenyl...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507736((R)-7-chloro-4-(3-fluoropyrrolidin-1- yl)-1-phenyl...)
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB