BDBM507790 4-[((2S,1R)-2- fluorocyclopropyl)amino]-1-(2- chlorophenyl)-7-cyclopropyl- hydroquinazolin-2-one::US11046691, Compound 413::US11084798, Cpd No 413::US11130759, Cpd. No. 413

SMILES F[C@H]1C[C@H]1Nc1nc(=O)n(-c2ccccc2Cl)c2cc(ccc12)C1CC1

InChI Key InChIKey=OFKNVVVDSFLNGX-JKSUJKDBSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
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Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 507790   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507790(4-[((2S,1R)-2- fluorocyclopropyl)amino]-1-(2- chlo...)
Affinity DataIC50: <200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507790(4-[((2S,1R)-2- fluorocyclopropyl)amino]-1-(2- chlo...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507790(4-[((2S,1R)-2- fluorocyclopropyl)amino]-1-(2- chlo...)
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent