BDBM507984 1-(2-chlorophenyl)-4-[(methylethyl)- amino]-7-(trifluoromethyl)pyrido[2,3- d]-pyrimidin-2(1H)-one::US11046691, Compound 258::US11084798, Cpd No 258::US11130759, Cpd. No. 258

SMILES CC(C)Nc1nc(=O)n(-c2ccccc2Cl)c2nc(ccc12)C(F)(F)F

InChI Key InChIKey=WTWPADOKHCZGPJ-UHFFFAOYSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 507984   

TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507984(1-(2-chlorophenyl)-4-[(methylethyl)- amino]-7-(tri...)
Affinity DataIC50: <200nMAssay Description:MAT2A enzyme is incubated with a test compound in DMSO or DMSO and its substrates (L-methionine and ATP) in a microtiter plate. The enzymatic reactio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507984(1-(2-chlorophenyl)-4-[(methylethyl)- amino]-7-(tri...)
Affinity DataIC50: <200nMAssay Description:Enzyme: MAT2AhMAT2A: 50 nM, Cepter, 10 mg/mL (234 μM), amino acids 1-395Substrates: 500 uM eachReaction time: 1 hourL-methionine Substrate: Alfa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetS-adenosylmethionine synthase isoform type-2(Human)
Ideaya Biosciences

US Patent
LigandPNGBDBM507984(1-(2-chlorophenyl)-4-[(methylethyl)- amino]-7-(tri...)
Affinity DataIC50: <200nMAssay Description:For the assay, a mixture of 1 mM L-methionine/1 mM ATP (2× final pre-stopped concentration) in assay buffer; MAT2A (2× final pre-stopped concentratio...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent