BDBM525153 Ac-QFR-kbt::N-0386::US10988505, Example 3

SMILES CC(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCNC(N)=N)C(=O)c1nc2ccccc2s1

InChI Key InChIKey=WWUOOSJKTRFWDJ-FKBYEOEOSA-N

Data  7 KI  1 IC50  3 EC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 11 hits for monomerid = 525153   

TargetTransmembrane protease serine 6(Homo sapiens (Human))
SociÉTÉ

US Patent
LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataKi:  0.506nMAssay Description:Enzymatic assays and Ki determination were performed at room temperature in an assay buffer containing 50 mM Tris-HCl, 150 mM NaCl and 500 μg/mL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetTransmembrane protease serine 6(Homo sapiens (Human))
SociÉTÉ

US Patent
LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataKi:  0.510nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataKi:  0.600nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine protease hepsin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataKi:  9.10nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProcathepsin L(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataKi:  6.29E+3nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProthrombin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataKi: >1.00E+4nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetFurin(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataKi: >1.00E+4nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTransmembrane protease serine 2(Homo sapiens (Human))
University Of British Columbia

LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataIC50:  3.90nMAssay Description:Vero E6 cells were transfected with mock (pcDNA3.1), TMPRSS2 (pcDNA3.1/TMPRSS2 Uniprot: O15393-1), or TMPRSS2-S441A (pcDNA3.1/TMPRSS2-S441A) using Li...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
University Of British Columbia

LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataEC50:  2.30nMAssay Description:Intracellular dose response (EC50 values) for selected compounds against SARS-CoV-2 were determined by pre-treating Calu-3 cells for three hr with se...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHemagglutinin()
SociÉTÉ

US Patent
LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataEC50:  2.28nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHemagglutinin(Influenza A virus (strain A/X-31 H3N2))
SociÉTÉ

US Patent
LigandPNGBDBM525153(Ac-QFR-kbt | N-0386 | US10988505, Example 3)
Affinity DataEC50:  34nMAssay Description:The ability of the tested compound to block influenza virus replication (PR8 and X31) in Calu-3 human bronchial epithelial cells was evaluated as des...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent