BDBM530298 WO2022064009, Compound 59

SMILES C[C@@H]1Cc2cnc(N[C@H]3CCC[C@H](O)C3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccccc1

InChI Key InChIKey=IRYRLBLRMDIRSC-ANQOARCNSA-N

Data  2 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
Find this compound or compounds like it in BindingDB:
   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 2 hits for monomerid = 530298   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530298(WO2022064009, Compound 59)
Affinity DataIC50:  5.25nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530298(WO2022064009, Compound 59)
Affinity DataIC50: <9.77nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Compounds with potencies approaching the limit o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed