BDBM530335 WO2022064009, Compound 120::WO2022064009, Compound 93

SMILES C[C@@H]1Cc2cnc(NC3CCOCC3)nc2CN1C(=O)[C@H]1CCN(C)C[C@@H]1c1ccc(F)cc1

InChI Key InChIKey=SAKVDYAGNDYVCG-MQNAVGNWSA-N

Data  3 IC50

  Tab Delimited (TSV)   2D SDfile   Computed 3D by Vconf -m prep SDfile
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Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 3 hits for monomerid = 530335   

TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530335(WO2022064009, Compound 120 | WO2022064009, Compoun...)
Affinity DataIC50:  12nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Compounds with potencies approaching the limit o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530335(WO2022064009, Compound 120 | WO2022064009, Compoun...)
Affinity DataIC50:  3.02nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Absorbance kinetic assay (5 nM CDK7/Cyclin H/MAT...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Janssen Pharmaceutica

WIPO
LigandPNGBDBM530335(WO2022064009, Compound 120 | WO2022064009, Compoun...)
Affinity DataIC50: <9.77nMAssay Description:Inhibition potencies of compounds were studied using an absorbance kinetic assay as described below. Compounds with potencies approaching the limit o...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed