BDBM530440 (R*)-7-Fluoro-6-(5-(1-hydroxyethyl)-1-methyl-1H-1,2,4-triazol-3-yl)-4-isopropyl- 2-(o-tolyl)isoquinolin-1(2H)-one.::WO2022070068, Example 12::WO2022070068, Example 21
SMILES CC(C)c1cn(-c2ccccc2C)c(=O)c2cc(F)c(cc12)-c1nc([C@@H](C)O)n(C)n1
InChI Key InChIKey=GFJXHYALUUKZRE-OAHLLOKOSA-N
Data 2 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 2 hits for monomerid = 530440
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Biotech
WIPO
Janssen Biotech
WIPO
Affinity DataIC50: 2nMAssay Description: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...More data for this Ligand-Target Pair
TargetDihydroorotate dehydrogenase (quinone), mitochondrial(Homo sapiens (Human))
Janssen Biotech
WIPO
Janssen Biotech
WIPO
Affinity DataIC50: 1.60nMAssay Description: To detect DHODH enzyme activities, dichloroindophenol (DCIP) is added as the final electron acceptor in the assay. DCIP can accept electrons from th...More data for this Ligand-Target Pair