BDBM534554 3-(2-amino-[1,2,4]triazolo[1,5-α]pyridin-7-yl)-N-(3,3-difluoro-3-(4-fluorophenyl)-2-hydroxypropyl)-2-fluoro-6-methylbenzamide::WO2018148626, Example 290::WO2022086828, Example 290
SMILES Cc1ccc(-c2ccn3nc(N)nc3c2)c(F)c1C(=O)NC[C@@H](O)C(F)(F)c1ccc(F)cc1
InChI Key InChIKey=ZJUJVFQXYFFLSK-QGZVFWFLSA-N
Data 4 IC50
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 4 hits for monomerid = 534554
Affinity DataIC50: 4.80nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:HT29-L23 human colorectal adenocarcinoma cells were maintained in RPMI 1640 medium containing 10% heat-inactivated FBS, 1% Penicillin-Streptomycin an...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb
WIPO
Bristol-Myers Squibb
WIPO
Affinity DataIC50: 4.80nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair
TargetReceptor-interacting serine/threonine-protein kinase 1(Homo sapiens (Human))
Bristol-Myers Squibb
WIPO
Bristol-Myers Squibb
WIPO
Affinity DataIC50: 0.5nMAssay Description:A solution was prepared containing 0.2 nM Anti GST-Tb (Cisbio, 61GSTTLB), 90.6 nM probe and 1 nM His-GST-TVMV-hRIPKl (1-324) in FRET Buffer (20 mM HE...More data for this Ligand-Target Pair