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BDBM5418 4-[6-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl]pyridine::pyrazolo[1,5-a]pyrimidine 2a

SMILES: Clc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1

InChI Key: InChIKey=GYUFUUYDYHBJEF-UHFFFAOYSA-N

Data: 1 IC50

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   Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 5418   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Vascular endothelial growth factor receptor 2


(Homo sapiens (Human))
BDBM5418
PNG
(4-[6-(4-chlorophenyl)pyrazolo[1,5-a]pyrimidin-3-yl...)
Show SMILES Clc1ccc(cc1)-c1cnc2c(cnn2c1)-c1ccncc1
Show InChI InChI=1S/C17H11ClN4/c18-15-3-1-12(2-4-15)14-9-20-17-16(10-21-22(17)11-14)13-5-7-19-8-6-13/h1-11H
PDB
MMDB

NCI pathway
Reactome pathway
KEGG

UniProtKB/SwissProt

DrugBank
antibodypedia
GoogleScholar
PC cid
PC sid
UniChem

Patents


Similars

Article
PubMed
n/an/a 113n/an/an/an/a7.422



Merck Research Laboratories



Assay Description
Activated KDR was incubated with 25 uM/10 uCi of [gamma-33P] ATP, poly-Glu/Tyr, and inhibitors in kinase buffer for 15 min at 22 °C. The reactio...


Bioorg Med Chem Lett 12: 2767-70 (2002)


Article DOI: 10.1016/s0960-894x(02)00525-5
BindingDB Entry DOI: 10.7270/Q2NG4NTG
More data for this
Ligand-Target Pair