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BDBM544834 US11286268, Compound 318

SMILES: Cc1c(c2cc(cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(csc12)C(O)=O)C(F)(F)F)S(C)(=O)=O

InChI Key: InChIKey=AVOYSCOGURUPLS-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544834   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544834
PNG
(US11286268, Compound 318)
Show SMILES Cc1c(c2cc(cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(csc12)C(O)=O)C(F)(F)F)S(C)(=O)=O
Show InChI InChI=1S/C29H19ClF3N3O6S2/c1-14-26(44(2,40)41)20-10-16(29(31,32)33)9-15(12-34)23(20)27(37)36(14)7-8-42-22-4-3-17(30)11-19(22)18-5-6-35-24-21(28(38)39)13-43-25(18)24/h3-6,9-11,13H,7-8H2,1-2H3,(H,38,39)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.92n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair