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BDBM544884 US11286268, Compound 367

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(F)c(CN4CCOCC4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=LPHAWLPCGUUPHD-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544884   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544884
PNG
(US11286268, Compound 367)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(F)c(CN4CCOCC4)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H27ClFN5O5S/c1-17-11-21(30-29(36-17)24(16-45-30)32(41)42)20-12-19(33)3-4-27(20)44-10-7-39-18(2)37-26-13-25(34)23(15-38-5-8-43-9-6-38)22(14-35)28(26)31(39)40/h3-4,11-13,16H,5-10,15H2,1-2H3,(H,41,42)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.87n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair