BindingDB logo
myBDB logout

BDBM544904 US11286268, Compound 390

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(Cc4ccccn4)nc3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=CJWOHXIAOGRGPE-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544904   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544904
PNG
(US11286268, Compound 390)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(Cc4ccccn4)nc3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C32H23ClF3N5O4S/c1-16-11-21(29-27(38-16)22(15-46-29)31(43)44)20-12-18(33)6-7-26(20)45-10-9-41-17(2)39-25-14-23(32(34,35)36)24(40-28(25)30(41)42)13-19-5-3-4-8-37-19/h3-8,11-12,14-15H,9-10,13H2,1-2H3,(H,43,44)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.75n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair