BindingDB logo
myBDB logout

BDBM544933 US11286268, Compound 419

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(C)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=AXMYTTLEPIHXSO-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544933   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM544933
PNG
(US11286268, Compound 419)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cnc(C)c(C#N)c3c2=O)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C27H20ClN5O4S/c1-13-8-18(25-24(31-13)20(12-38-25)27(35)36)17-9-16(28)4-5-22(17)37-7-6-33-15(3)32-21-11-30-14(2)19(10-29)23(21)26(33)34/h4-5,8-9,11-12H,6-7H2,1-3H3,(H,35,36)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 1.08n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair