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BDBM544984 US11286268, Compound 469

SMILES: Cc1cc(c(C)cn1)-c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)(F)F

InChI Key: InChIKey=RWZDORHFRNCFGN-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 544984   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))		BDBM544984
PNG
(US11286268, Compound 469)
Show SMILES Cc1cc(c(C)cn1)-c1c(cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c1C#N)C(F)(F)F
Show InChI InChI=1S/C35H25ClF3N5O4S/c1-16-14-41-17(2)9-21(16)29-24(13-40)30-27(12-26(29)35(37,38)39)43-19(4)44(33(30)45)7-8-48-28-6-5-20(36)11-22(28)23-10-18(3)42-31-25(34(46)47)15-49-32(23)31/h5-6,9-12,14-15H,7-8H2,1-4H3,(H,46,47)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.25n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...

US Patent US11286268 (2022)

More data for this
Ligand-Target Pair