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BDBM545084 US11286268, Compound 569

SMILES: Cc1nc2cc(cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(csc12)C(=O)NS(C)(=O)=O)C(F)(F)F

InChI Key: InChIKey=JTPCTPVJRNZFNT-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545084   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545084
PNG
(US11286268, Compound 569)
Show SMILES Cc1nc2cc(cc(C#N)c2c(=O)n1CCOc1ccc(Cl)cc1-c1ccnc2c(csc12)C(=O)NS(C)(=O)=O)C(F)(F)F
Show InChI InChI=1S/C28H19ClF3N5O5S2/c1-14-35-21-10-16(28(30,31)32)9-15(12-33)23(21)27(39)37(14)7-8-42-22-4-3-17(29)11-19(22)18-5-6-34-24-20(13-43-25(18)24)26(38)36-44(2,40)41/h3-6,9-11,13H,7-8H2,1-2H3,(H,36,38)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair