BDBM545105 US11286268, Compound 590

SMILES: CC1C=C(c2scc(C(O)=O)c2N1=O)c1cc(Cl)ccc1OCCn1c(C)nc2cc(cc(C#N)c2c1=O)C(F)(F)F

InChI Key: InChIKey=HQOLKMRWKJTXHA-UHFFFAOYSA-N

Data: 1 IC50

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545105   

Target/Host (Institution)	Ligand	Target/Host Links	Ligand Links	Trg + Lig Links	Ki nM	ΔG° kcal/mole	IC50 nM	Kd nM	EC50 nM	koff s-1	kon M-1s-1	pH	Temp °C
Eukaryotic translation initiation factor 4E-binding protein 1 (Homo sapiens (Human))	BDBM545105 (US11286268, Compound 590) Show SMILES CC1C=C(c2scc(C(O)=O)c2N1=O)c1cc(Cl)ccc1OCCn1c(C)nc2cc(cc(C#N)c2c1=O)C(F)(F)F Show InChI InChI=1S/C28H19ClF3N4O5S/c1-13-7-19(25-24(36(13)40)20(12-42-25)27(38)39)18-10-17(29)3-4-22(18)41-6-5-35-14(2)34-21-9-16(28(30,31)32)8-15(11-33)23(21)26(35)37/h3-4,7-10,12-13H,5-6H2,1-2H3,(H,38,39)	PDB KEGG UniProtKB/SwissProt GoogleScholar	UniChem	US Patent	n/a	n/a	2.26	n/a	n/a	n/a	n/a	n/a	n/a
eFFECTOR Therapeutics, Inc. US Patent					Assay Description eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...				US Patent US11286268 (2022)
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