BindingDB logo
myBDB logout

BDBM545105 US11286268, Compound 590

SMILES: CC1C=C(c2scc(C(O)=O)c2N1=O)c1cc(Cl)ccc1OCCn1c(C)nc2cc(cc(C#N)c2c1=O)C(F)(F)F

InChI Key: InChIKey=HQOLKMRWKJTXHA-UHFFFAOYSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545105   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545105
PNG
(US11286268, Compound 590)
Show SMILES CC1C=C(c2scc(C(O)=O)c2N1=O)c1cc(Cl)ccc1OCCn1c(C)nc2cc(cc(C#N)c2c1=O)C(F)(F)F
Show InChI InChI=1S/C28H19ClF3N4O5S/c1-13-7-19(25-24(36(13)40)20(12-42-25)27(38)39)18-10-17(29)3-4-22(18)41-6-5-35-14(2)34-21-9-16(28(30,31)32)8-15(11-33)23(21)26(35)37/h3-4,7-10,12-13H,5-6H2,1-2H3,(H,38,39)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.26n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair