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BDBM545132 US11286268, Compound 618

SMILES: CN(Cc1cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c(C#N)c1OC(F)F)C(C)(C)C

InChI Key: InChIKey=WRSTZBIWTPVKRP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545132   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545132
PNG
(US11286268, Compound 618)
Show SMILES CN(Cc1cc2nc(C)n(CCOc3ccc(Cl)cc3-c3cc(C)nc4c(csc34)C(O)=O)c(=O)c2c(C#N)c1OC(F)F)C(C)(C)C
Show InChI InChI=1S/C34H32ClF2N5O5S/c1-17-11-22(30-28(39-17)24(16-48-30)32(44)45)21-13-20(35)7-8-26(21)46-10-9-42-18(2)40-25-12-19(15-41(6)34(3,4)5)29(47-33(36)37)23(14-38)27(25)31(42)43/h7-8,11-13,16,33H,9-10,15H2,1-6H3,(H,44,45)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 2.98n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair