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BDBM545145 US11286268, Compound 631

SMILES: Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4ccccn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1

InChI Key: InChIKey=RBLSFPIEGOLKPP-UHFFFAOYSA-N

Data: 1 IC50

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Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545145   
Target/Host
(Institution)
LigandTarget/Host
Links
Ligand
Links
Trg + Lig
Links
Ki
nM
ΔG°
kcal/mole
IC50
nM
Kd
nM
EC50
nM
koff
s-1
kon
M-1s-1
pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))
BDBM545145
PNG
(US11286268, Compound 631)
Show SMILES Cc1cc(-c2cc(Cl)ccc2OCCn2c(C)nc3cc(c(-c4ccccn4)c(C#N)c3c2=O)C(F)(F)F)c2scc(C(O)=O)c2n1
Show InChI InChI=1S/C33H21ClF3N5O4S/c1-16-11-20(30-29(40-16)22(15-47-30)32(44)45)19-12-18(34)6-7-26(19)46-10-9-42-17(2)41-25-13-23(33(35,36)37)27(24-5-3-4-8-39-24)21(14-38)28(25)31(42)43/h3-8,11-13,15H,9-10H2,1-2H3,(H,44,45)
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.41n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...


US Patent US11286268 (2022)

More data for this
Ligand-Target Pair