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BDBM545156 US11286268, Compound 642

SMILES: C[C@H]1CN(Cc2c(cc3nc(C)n(CCOc4ccc(Cl)cc4-c4cc(C)nc5c(csc45)C(O)=O)c(=O)c3c2C#N)C(F)(F)F)C[C@@H](C)O1

InChI Key: InChIKey=RJWMRXDFSBCQIX-KDURUIRLSA-N

Data: 1 IC50

Find this compound or compounds like it in BindingDB:
Substructure
Similarity at least:  must be >=0.5
Exact match

Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB

Found 1 hit for monomerid = 545156   
Target/Host
(Institution)		LigandTarget/Host
Links		Ligand
Links		Trg + Lig
Links		Ki
nM		ΔG°
kcal/mole		IC50
nM		Kd
nM		EC50
nM		koff
s-1		kon
M-1s-1		pHTemp
°C
Eukaryotic translation initiation factor 4E-binding protein 1


(Homo sapiens (Human))		BDBM545156
PNG
(US11286268, Compound 642)
Show SMILES C[C@H]1CN(Cc2c(cc3nc(C)n(CCOc4ccc(Cl)cc4-c4cc(C)nc5c(csc45)C(O)=O)c(=O)c3c2C#N)C(F)(F)F)C[C@@H](C)O1
Show InChI InChI=1S/C35H31ClF3N5O5S/c1-17-9-23(32-31(41-17)26(16-50-32)34(46)47)22-10-21(36)5-6-29(22)48-8-7-44-20(4)42-28-11-27(35(37,38)39)25(24(12-40)30(28)33(44)45)15-43-13-18(2)49-19(3)14-43/h5-6,9-11,16,18-19H,7-8,13-15H2,1-4H3,(H,46,47)/t18-,19+
PDB

KEGG

UniProtKB/SwissProt

GoogleScholar
UniChem
US Patent
n/an/a 3.63n/an/an/an/an/an/a



eFFECTOR Therapeutics, Inc.

US Patent


Assay Description
eIF4E protein was pre-incubated with EDA-m7GDP-ATTO-550 in FPB at 2xconcentrations for 5 minutes prior to the addition of compounds. Compounds (100x)...

US Patent US11286268 (2022)

More data for this
Ligand-Target Pair